Expect to meet new shape-shifters, warlocks and other unclassified supernatural types. Apparently, "things get really, weird very fast".
Newsbeat entertainment reporter Chi Chi Izundu talks to one of the stars Alex Skarsgard.
His character, Eric, finds love this time round but in real life he says "he doesn't bite people".
True Blood season two starts at 10pm on Friday 26 February on digital channel FX.